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. 2022 Dec 28;14(1):92. doi: 10.3390/genes14010092

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Interchromosomal relationships between centromeric satellite DNA and pericentromeric segmental duplications. Circos plots showing sequence relationships among four different satellite families as well as pericentromeric segmental duplications in the T2T-CHM13 genome. Connecting line widths for satellite families indicate the proportion of 75-mers shared between arrays (i.e., thicker lines indicate greater overall sequence similarity between different arrays of the same family). α-satellite lines are colored by their suprachromosomal family (SF) assignment. Radial bar plots indicate specificity of 75-mers proportionally, with white indicating 75-mers unique to the array, light gray indicating 75-mers shared with other centromeric regions, and black indicating 75-mers shared with regions outside of centromeres. The pericentromeric segmental duplication circos plot shows pairwise alignments between pericentromeric regions that are >1 kbp and >90% identical.