TABLE 2.
Antibiotic and Immunosuppressant Use After Diagnosis of SSTI in Subjects With and Without Recurrent Colonization With MRSA
| Drug | Recurrent MRSA colonization (N = 85) | No recurrent MRSA colonization (N = 110) | P value |
|---|---|---|---|
| First 14 days | |||
| Antibiotics | 80 (94.1) | 103 (93.6) | .890 |
| Amoxicillin-clavulanate | 7 (8.2) | 2 (1.8) | .043 |
| Cephalexin | 7 (8.2) | 4 (3.6) | .215 |
| Clindamycin | 32 (37.6) | 67 (60.9) | .001 |
| Doxycycline | 3 (3.5) | 7 (6.4) | .518 |
| Trimethoprim-sulfamethoxazole | 45 (52.9) | 38 (34.5) | .010 |
| Mupirocin | 20 (23.5) | 19 (17.3) | .279 |
| Bleach bath/chlorhexidine | 15 (17.6) | 19 (17.3) | .946 |
| Steroids | |||
| Oral corticosteroids | 6 (7.1) | 4 (3.6) | .337 |
| Intranasal steroids | 3 (3.5) | 6 (5.5) | .734 |
| Day 15 through clearance of colonization | |||
| Antibiotics | 12 (14.1) | 16 (14.5) | .933 |
| Cephalexin | 1 (1.2) | 0 (0) | .436 |
| Clindamycin | 2 (2.4) | 6 (5.5) | .470 |
| Doxycycline | 2 (2.4) | 3 (2.7) | >.99 |
| Trimethoprim-sulfamethoxazole | 5 (5.9) | 5 (4.5) | .750 |
| Mupirocin | 7 (8.2) | 9 (8.2) | .932 |
| Bleach bath/chlorhexidine | 16 (18.8) | 23 (20.9) | .813 |
| Steroids | |||
| Oral corticosteroids | 2 (2.4) | 5 (4.5) | .472 |
| Intranasal steroids | 3 (3.5) | 6 (5.5) | .734 |
| Clearance of colonization to recurrence or end of follow-up | |||
| Antibiotics | 25 (29.4) | 31 (28.2) | .737 |
| Amoxicillin-clavulanate | 1 (1.2) | 1 (0.9) | >.99 |
| Azithromycin | 3 (3.5) | 0 (0) | .077 |
| Cephalexin | 1 (1.2) | 1 (0.9) | >.99 |
| Clindamycin | 9 (10.6) | 14 (12.7) | .713 |
| Doxycycline | 1 (1.2) | 2 (1.8) | >.99 |
| Trimethoprim-sulfamethoxazole | 10 (11.8) | 11 (10.0) | .634 |
| Mupirocin | 7 (8.2) | 8 (7.3) | .749 |
| Bleach bath/chlorhexidine | 14 (16.5) | 18 (16.4) | .899 |
| Steroids | |||
| Oral corticosteroids | 3 (3.5) | 5 (4.5) | >.99 |
| Intranasal steroids | 2 (2.4) | 5 (4.5) | .702 |