Table 1.
Baseline Characteristics
| Characteristic | COPDGene (n = 4,635) |
PLuSS (n = 1,307) |
||
|---|---|---|---|---|
| Visit 1 | Visit 2 | Visit 1 | Visit 2 | |
| Time from visit 1 (mean ± SD), y | … | 5.6 ± 0.8 | … | 8.6 ± 2.8 |
| Age (mean ± SD), y | 59.9 ± 8.7 | 65.5 ± 8.7 | 61.0 ± 6.6 | 69.6 ± 6.4 |
| Sex | ||||
| Female | 2,426 (52.3) | 506 (38.7) | ||
| Male | 2,209 (47.7) | 801 (61.3) | ||
| Self-reported race | ||||
| American Indian/Alaskan Native | … | 2 (0.2) | ||
| Asian | … | 2 (0.2) | ||
| Black | 1,351 (29.1) | 55 (4.2) | ||
| Pacific Islander | … | 1 (0.1) | ||
| Non-Hispanic White | 3,284 (70.9) | 1,247 (95.4) | ||
| Smoking | ||||
| Former | 2,431 (52.4) | 2,840 (61.4) | 484 (40.8) | …a |
| Current | 2,204 (47.6) | 1,785 (38.6) | 701 (59.2) | …a |
| Pack-years, mean ± SD | 41.9 ± 23.9 | 43.3 ± 24.3 | 65.0 ± 22.5 | …a |
| BMI (mean ± SD), kg/m2 | 29.1 ± 6.1 | 29.0 ± 6.4 | 28.5 ± 5.2 | 28.7 ± 5.4 |
| Pulmonary function | ||||
| Time between CT scan and PFTs (mean ± SD), d | 1.1 ± 25.7 | 0.6 ± 12.0 | 29.4 ± 16.0 | 34.1 ± 20.3 |
| Prebronchodilator FEV1 (mean ± SD), L | 2.2 ± 0.8 | 2.0 ± 0.8 | 2.5 ± 0.8 | 2.1 ± 0.8 |
| Prebronchodilator FVC (mean ± SD), L | 3.2 ± 1.0 | 3.0 ± 0.9 | 3.6 ± 1.0 | 3.2 ± 1.0 |
| Baseline lung function | ||||
| Preserved ratio impaired spirometry (PRISm) | 563 (12.2) | …a | … | |
| Without spirometric limitations (GOLD stage 0) | 2,122 (46.0) | …a | … | |
| With COPD (GOLD stages 1-4) | 1,874 (40.6) | … | … | |
| 6-Min walk distance, m | 437.2 ± 112.6 | 393.8 ± 132.3 | … | … |
| Quantitative CT measures | ||||
| Percentage of lung occupied by QIAs, mean ± SD | 6.0 ± 4.6 | 5.7 ± 4.6 | 16.2 ± 7.8 | 15.9 ± 6.5 |
| Percentage of lung occupied by emphysema, mean ± SD | 6.8 ± 12.9 | 6.2 ± 13.4 | 10.2 ± 4.2 | 11.7 ± 4.2 |
| Percentage of lung occupied by normal parenchyma, mean ± SD | 87.2 ± 13.3 | 87.8 ± 14.1 | 66.6 ± 7.3 | 65.6 ± 6.4 |
| Mortality | ||||
| Alive | 4,386 (94.6) | 1,033 (79.0) | ||
| Dead | 249 (5.4) | 274 (21.0) | ||
| Survival duration from enrollment (mean ± SD), y | 8.3 ± 1.2 | 12.0 ± 1.9 | ||
Data displayed as No. (%) unless otherwise specified. COPDGene = Genetic Epidemiology of COPD; PFTs = pulmonary function tests; PLuSS = Pittsburgh Lung Screening Study; QIAs = quantitative interstitial abnormalities.
a
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