Table 3.
Associations Between Rate of Quantitative Interstitial Abnormality Progression and Rate of Change in FVC and 6-Min Walk Distance Between Visits 1 and 2
| FVC (mL/y) |
6-Min Walk Distance (m/y) |
|||
|---|---|---|---|---|
| Cohort | Effect,a Mean (95% CI) | P Value | Effect,a Mean (95% CI) | P Value |
| COPDGene | –8.5 (–12.4 to –4.7) | < .001 | –1.2 (–2.3 to –0.2) | .021 |
| PLuSS | –9.5 (–15.4 to –3.7) | .001 | …b | …b |
Adjusted for age; sex; self-reported race; baseline: quantitative interstitial abnormalities, emphysema, airway wall thickness (COPDGene only), smoking status, pack-years, and BMI; and change in: emphysema, smoking status (COPDGene only), BMI, and scanner manufacturer. Associations with change in 6-min walk distance also adjusted for baseline and change in FEV1. COPDGene = Genetic Epidemiology of COPD; PLuSS = Pittsburgh Lung Screening Study.
Effect expressed as the association between the annual rate of change (percent per year) in quantitative interstitial abnormalities and rate of change in the clinical outcome.
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