TABLE 1.
Comparison of clinicopathological features according to circCAPRIN1 expression in 259 colorectal cancer patients
| circCAPRIN1 expression, n (%) | ||||
|---|---|---|---|---|
| Clinicopathological feature | Low expression (n = 106) | High expression (n = 153) | P value | |
| Age (years) | 0.900 | |||
| ≤60 | 65 (61.3) | 95 (62.1) | ||
| >60 | 41 (38.7) | 58 (37.9) | ||
| Sex | 0.746 | |||
| Male | 63 (59.4) | 94 (61.4) | ||
| Female | 43 (40.6) | 59 (38.6) | ||
| Location | 0.276 | |||
| Colon | 53 (50.0) | 66 (43.1) | ||
| Rectum | 53 (50.0) | 87 (56.9) | ||
| Histologic type | 0.179 | |||
| Adenocarcinoma | 103 (97.2) | 143 (93.5) | ||
| Mucinous | 3 (2.8) | 10 (6.5) | ||
| Differentiation | 0.042 | |||
| Poor | 14 (13.2) | 38 (24.8) | ||
| Moderate/ Well | 88 (83.0) | 106 (69.3) | ||
| Unknown | 4 (3.8) | 9 (5.9) | ||
| CEA status | 0.532 | |||
| Normal | 69 (65.1) | 89 (58.2) | ||
| Elevated | 33 (31.1) | 57 (37.3) | ||
| Unknown | 4 (3.8) | 7 (4.6) | ||
| T stage | 0.074 | |||
| T1* | 0 (0) | 0 (0) | ||
| T2 | 21 (19.8) | 20 (13.1) | ||
| T3 | 24 (22.6) | 24 (15.7) | ||
| T4 | 61 (57.5) | 109 (71.2) | ||
| N stage | 0.002 | |||
| N0 | 58 (54.7) | 55 (35.9) | ||
| N1 | 31 (29.2) | 46 (30.1) | ||
| N2 | 17 (16.0) | 52 (34.0) | ||
| M stage | 0.026 | |||
| M0 | 96 (90.6) | 123 (80.4) | ||
| M1 | 10 (9.4) | 30 (19.6) | ||
| Stage | 0.006 | |||
| I | 13 (12.3) | 8 (5.2) | ||
| II | 38 (35.8) | 36 (23.5) | ||
| III | 45 (42.5) | 79 (51.6) | ||
| IV | 10 (9.4) | 30 (19.6) | ||
| Perineural invasion | 0.197 | |||
| Absent | 94 (88.7) | 126 (82.4) | ||
| Present | 12 (11.3) | 26 (17.0) | ||
| Unknown | 0 (0) | 1 (0.6) | ||
| Vascular invasion | 0.059 | |||
| Absent | 80 (75.5) | 94 (61.4) | ||
| Present | 25 (23.6) | 56 (36.6) | ||
| Unknown | 1 (0.9) | 3 (2.0) | ||
*
T1 patients were excluded from analysis due to limited tumor size.
Abbreviations: CEA, carcinoembryonic antigen.