FIGURE 2.

The frequency of RAS mutations in human malignancies. The isoforms, position and type of substitution of RAS mutations vary by tissue types in clinical observations. (A) The frequency of the most common isoforms of RAS mutations across tumor types. (B) Distribution of different position of substitution of KRAS, NRAS and HRAS mutations across tumor types. (C) Distribution of KRAS mutations that are in G12 for pancreatic, lung and colorectal cancers and that of NRAS mutations that are in Q61 for melanoma and thyroid cancer. Data are acquired from GENIE (Version 10.1). Abbreviations: PDAC, pancreatic ductal adenocarcinoma; LUAD, lung adenocarcinoma; CRC, colorectal cancer. HNSCC, head and neck squamous cell cancer