Extended Data Fig. 2.

Each panel shows a slice from one of the tomograms in Fig. 2 b,e processed in the following way: (left) cryoCARE-denoised (see Materials and Methods for details), (center) back-projected volume generated using IMOD without further processing, (right) the same volume processed using nonlinear anisotropic diffusion algorithm in IMOD (k = 0.5, 50 iterations). Unprocessed tomograms are available from EMDB using the accession numbers provided for each condition. Experiments were repeated three times, representative images from one repeat are shown.