Fig. 1. Differential gene expression in chemoresistant OS models.

Gene expression data for in vitro studies was extracted into a data table and entered into R to develop a summary heatmap of gene expression for each distinct model. Genes are organised from most (top) to least (bottom) investigated across different models. Models are ordered by the MAP agent used for generation. (Blue) Downregulated, (Red) Upregulated, (Grey) Unchanged with respect to corresponding parental cell line, (Black) unknown or ambiguous results signifying an area of potential research interest. Genes involved in drug efflux are highlighted due to their occurrence (number of studies = 22).