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. 2022 Nov 25;42(4):259–277. doi: 10.1038/s41388-022-02529-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — ncRNA expression data for in vitro studies was extracted into a data table and entered into R to develop a summary heatmap of expression grouped by distinct model. ncRNAs are organised from most (top) to least (bottom) investigated across different models. Models are ordered by the MAP agent used for generation. (Blue) Downregulated, (Red) Upregulated, (Grey) Unchanged with respect to each models’ corresponding parental cell line, (Purple) Differing expression results within the same model, (Black) unknown or ambiguous result indicating an area of potential research interest. ncRNAs shown to be involved in the regulation of drug efflux proteins are highlighted due to their occurrence (number of studies = 15).