Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 9;25(1):108–119. doi: 10.1038/s41556-022-01042-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a, Fold regulation of candidate genes expression validated by RT–qPCR in A375M2 compared with A375P. b, Fold regulation of OSBPL8, TOR1AIP1 and SUMO1 expression validated by RT–qPCR in metastatic melanoma WM983B cells compared with primary melanoma WM983A cells. c, Heat maps displaying fold change in expression of candidate genes in melanoma cell lines compared with melanocytes from Philadelphia and Mannheim datasets. d, TOR1AIP1 expression in primary tumours and metastasis in Kabbarah (n = 31 and 73, respectively), Riker (n = 14 and 40, respectively) and Xu (n = 31 and 52, respectively) melanoma patient datasets. Experimental data have been pooled from three individual experiments. In a and b, bar charts show the mean and error bars represent s.e.m. from N = 3 independent experiments. In d, horizontal lines show the median and whiskers show minimum and maximum range of values. P values calculated by two-tailed unpaired t-test (a–d); *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Numerical data and exact P values are available in source data.

Source data