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. 2023 Jan 20;14:341. doi: 10.1038/s41467-023-35922-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Protein lysates from EXD2^+/+, EXD2^−/−-cl1, EXD2^−/− + EXD2^WT-cl1 and EXD2^−/− + EXD2^D108A/E110A-cl1 cells were immuno-blotted for proteins as indicated. Molecular mass of the proteins is indicated (kDa). Source data are provided as a Source Data file. b Cells were mock- or UV-irradiated (15 J/m²) and mRNA was labeled with EU at the indicated time points post-UV. EU signal was quantified by ImageJ and relative integrated densities, normalized to mock-treated level set to 100%, are reported on the graph (n = at least 20 cells per conditions). Red bars indicate mean integrated density. RT recovery time. One-way ANOVA with post-hoc Tukey adjustment comparisons were used to determine the p-values. Source data are provided as a Source Data file. c Representative confocal images of EXD2^−/− + EXD2^WT-cl1 and EXD2^−/− + EXD2^D108A/E110A-cl1 treated like in b. Images of the cells were obtained with the same microscopy system and constant acquisition parameters.