Given the analytical limitations of the D3-Cr dilution test, the group recommends not using the method in pharmacological trials at present. In addition to the need for a more widely available method, the group also identified that the method should be validated in other cohorts before any recommendation in clinical trials. Therefore, also taking into account that it is presently the only analytical test highly specific to muscle mass, the group concluded that muscle mass should be assessed according to the EWGSOP2 revised definition without additional biochemical markers