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. 2022 Dec 28;97(2):523–545. doi: 10.1007/s00204-022-03436-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Intersection of upregulated DEGs for the top concentrations of 1,2-DCVC and 1,2-DCVG exposure across cell models. Number of DEGs: number of upregulated DEGs found for cell model (padj < 0.01, basemean > 35, log2FC > 0.58). Genes intersection: Number of DEGs found in common for depicted cell models (black or red dots) a 1,2-DCVC exposure. Six genes found commonly upregulated across the cell panel: Heme Oxygenase 1 (HMOX1), Glutamate-Cysteine Ligase (GCLM) and Ferritin Light Chain (FTL), DNA Damage Inducible Transcript 3 (DDIT3), Tribbles Pseudokinase 3 (TRIB3) and Asparagine Synthetase (Glutamine-Hydrolyzing) (ASNS). b 1,2-DCVG exposure. UKN5 were not tested for 1,2-DCVG exposure and therefore not included in the analysis. No DEGs were found after 1,2-DCVG exposure in LUHMES. RPTEC/TERT1, HUVEC/TERT2 and HepaRG demonstrated three genes commonly upregulated, HMOX1, GCLM and Tripartite Motif Containing 16 Like (TRIM16L)