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. 2022 Dec 28;97(2):523–545. doi: 10.1007/s00204-022-03436-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — TCE conjugates concentration vs mRNA raw counts response of selected gene representing three major stress response pathways suggested by over-representation analysis using CPDB. a Nrf2—Oxidative stress: Heme Oxygenase 1 (HMOX1), Glutamate-Cysteine Ligase (GCLM) and Ferritin Light Chain (FTL). b UPR- Unfolded protein response: Inducible Transcript 3 (DDIT3), Tribbles Pseudokinase 3 (TRIB3) and Asparagine Synthetase (Glutamine-Hydrolyzing) (ASNS). c P53-responses: Growth Arrest And DNA Damage Inducible Alpha (GADD45A), MDM2 Proto-Oncogene (MDM2), Snail Family Transcriptional Repressor 2 (SNAI2)

Fig. 6 — TCE conjugates concentration vs mRNA raw counts response of selected gene representing three major stress response pathways suggested by over-representation analysis using CPDB. a Nrf2—Oxidative stress: Heme Oxygenase 1 (HMOX1), Glutamate-Cysteine Ligase (GCLM) and Ferritin Light Chain (FTL). b UPR- Unfolded protein response: Inducible Transcript 3 (DDIT3), Tribbles Pseudokinase 3 (TRIB3) and Asparagine Synthetase (Glutamine-Hydrolyzing) (ASNS). c P53-responses: Growth Arrest And DNA Damage Inducible Alpha (GADD45A), MDM2 Proto-Oncogene (MDM2), Snail Family Transcriptional Repressor 2 (SNAI2)