Table 2.

Comparison of fold increases of a selection of differentially expressed genes in cell models exposed for 24 h to 62,5 µM 1,2-DCVC

Differentially expressed genes	Associated stress response pathway(s)	RPTEC/ TERT1	HepaRG	HUVEC/ TERT2	LUHMES	BCC42	UKN5
HMOX1	a, d	23	13	3.9	22	35	2.0
GCLM	a, d	6.0	2.4	1.9	8.1	6.1	< 1.5
FTL	a, d	4.6	2.5	1.7	4.1	3.9	< 1.5
UGT1A6	a, e	8.7	< 1.5	< 1.5	< 1.5	< 1.5	< 1.5
UGT1A8	a	7.8	< 1.5	< 1.5	< 1.5	< 1.5	< 1.5
UGT1A10	a	7.9	< 1.5	< 1.5	< 1.5	< 1.5	< 1.5
SRXN1	a	7.0	4.6	1.7	< 1.5	21	< 1.5
CEBPB	a	3.0	< 1.5	1.6	112	4.2	< 1.5
SLC7A11	a	< 1.5	7.7	2.7	< 1.5	5.6	< 1.5
NMRAL2P	a	25	< 1.5	9.2	< 1.5	33	< 1.5
OSGIN1	a	14	3.9	2.3	< 1.5	30	< 1.5
NQO1	a	8.4	< 1.5	2.6	15	4.4	2.3
TXNRD1	a, e	21	< 1.5	1.9	3.0	4.3	< 1.5
DDIT3	b	7.7	4.4	< 1.5	17	5.8	< 1.5
ASNS	b	5.3	3.1	< 1.5	7.8	4.0	< 1.5
TRIB3	b	4.5	5.3	< 1.5	70	10	< 1.5
TRIM16L	b	6.6	1.8	3.8	6.3	8.1	< 1.5
GDF15	b, g	7.0	5.7	< 1.5	11	16	< 1.5
GADD45A	c	11	1.8	< 1.5	< 1.5	5.7	< 1.5
SNAI2	c	4.3	2.1	< 1.5	< 1.5	< 1.5	< 1.5
MDM2	c	< 1.5	< 1.5	1.6	< 1.5	5.1	< 1.5
TNFRSF10B	c	1.9	< 1.5	< 1.5	4.1	3.0	< 1.5
SLC7A5	e	4.7	5.1	5.5	40	< 1.5	< 1.5
ME1	e	1.8	< 1.5	< 1.5	13	< 1.5	< 1.5
CHAC1	f	< 1.5	< 1.5	< 1.5	< 1.5	45	< 1.5
ATF5	f	< 1.5	2.1	< 1.5	29	< 1.5	< 1.5

Numbers represent fold-increases of DEGs relative to the medium controls; numbers in bold represent the largest fold increase across the six cell models; associated stress pathways correspond to pathways found from over-representation analysis using the online tool http://cpdb.molgen.mpg.de from 1,2-DCVC exposures; a, Nrf2-response; b, UPR-response; c, p53-signalling; d, Ferroptosis; e, Nuclear receptor Meta-pathway; f, Response to heme deficiency; g, Mitochondrial stress response