Table 3.
Component Loadings, Unstandardized Mean/Variance, and Standard Errors of Measurement From All Cohorts Last Visits and Cohort-Specific Longitudinal CFAs
| Model | Neuropsychological test/item | ADNI | HABS | AIBL | A4 |
|---|---|---|---|---|---|
| N | 795 | 427 | 1,176 | 4,492 | |
| Std loading | |||||
| Last visit model | MMSE | 0.559a | 0.559a | 0.559a | 0.559a |
| LMDR | 0.633a | 0.633a | 0.633a | — | |
| LMDR_A4 | — | — | — | 0.281 | |
| Digit symbol | — | 0.717b | — | 0.717b | |
| Digit symbol AIBL | — | — | 0.659 | — | |
| FCSRT trial 1 | — | 0.646b | — | 0.646b | |
| FCSRT trial 2 | — | 0.683b | — | 0.683b | |
| FCSRT trial 3 | — | 0.620b | — | 0.620b | |
| Trails B | 0.608 | — | — | — | |
| ADAS-cog | 0.596 | — | — | — | |
| Animals | 0.588+ | 0.588a | 0.588a | — | |
| Vegetables | — | 0.706 | — | — | |
| Fruits | — | 0.695 | 0.695 | — | |
| Names | — | — | 0.658 | — | |
| Furniture | — | — | 0.676 | — | |
| CVLT | — | — | 0.719 | — | |
| Longitudinal model | Mean/variance | 0.241/0.567 | 0.823/0.951 | −0.312/0.618 | 0.240/0.431 |
| SEM mean(SD) | 0.50 (0.04) | 0.28 (0.07) | 0.32 (0.05) | 0.34 (0.02) |
Note. Std = standardized; SEM = standard error of measurement; ADNI = Alzheimer’s Disease Neuroimaging Initiative; HABS = Harvard Aging Brain Study; CFA = confirmatory factor analysis; AIBL = Australian Imaging, Biomarker and Lifestyle Study of Ageing; A4 = Anti-Amyloid Treatment of Asymptomatic Alzheimer’s Disease; MMSE = Mini-Mental State Examination; LMDR = logical memory delayed recall; FCSRT = Free and Cued Selective Reminding Test; ADAS = Alzheimer’s disease Assessment Scale; CVLT = California Verbal Learning Test.
Tests that overlap between cohorts have their loadings locked in the base model.
Shared loadings for the secondary model to A4.