Figure 6:

Multiple inflammatory mechanisms drive inflammation-fibrosis coupling post-myocardial infarction. (A) Cell sources of TGFβ post MI, followed by fibroblasts. (B) Roles of inflammatory cytokines IL-1β, GM-CSF, and TNFa in TGFβ secretion post MI. (C) Effect of inflammatory cytokines on cell counts, debris, and phagocytosis. (D) Effects of various phagocytosis mechanisms on overall and macrophage TGFβ secretion. The relative area under the curve represents a cumulative sum of the secreted factors in simulated time course.