Table 3:
Parameter values for cell behavior derived from literature and optimized using parameter estimation.
| Parameter | Description | Value | Unit | Measurement techniques | Citation |
|---|---|---|---|---|---|
| Cardiomyocyte parameters | |||||
| αCM | Apoptosis rate | 0.025 | 1/hour | -- | Estimated value |
| Neutrophil parameters | |||||
| IN | Infiltration rate | 0.095 | 1/hour | -- | Estimated value |
| αN | Removal rate | 0.525 | 1/hour | -- | Estimated value |
| ϕN | Phagocytosis rate | 2.2e-3 | 1/hour | -- | Estimated value |
| Monocyte parameters | |||||
| IMo | Infiltration rate | 0.095 | 1/hour | -- | Estimated value |
| αMo | Removal rate | 0.525 | 1/hour | -- | Estimated value |
| λMo,blood | Proliferation rate in blood | 1e-5 | 1/hour | -- | Estimated value |
| Macrophage parameters | |||||
| dM | Differentiation rate from monocytes | 0.0592 | dimensionless | Flow cytometry | (Nahrendorf et al., 2007) |
| λM | Proliferation rate | 2.3e-4 | 1/hour | Bromodeoxyuridine (BrdU) incorporation assay | (Heidt et al., 2014) |
| αM | Removal rate | 0.0175 | 1/hour | -- | Estimated value |
| ϕM | Phagocytosis rate | 0.015 | 1/hour | -- | Estimated value |
| Fibroblast parameters | |||||
| λF | Proliferation rate | 0.065 | 1/hour | Bromodeoxyuridine (BrdU) incorporation assay | (Virag & Murry, 2003) |
| αF | Removal rate | 1.5e-3 | 1/hour | -- | Estimated value |