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. 2023 Jan 20;14(1):45. doi: 10.1038/s41419-023-05557-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Serum creatinine (Scr) and urea nitrogen (BUN) levels were measured in each group (n = 6). B Images of hematoxylin-eosin (HE) staining (n = 6). Scale bars, 100 μm; Terminal deoxynucleotidyl transferase–mediated dUTP nick end-labelling (TUNEL) assay were used to evaluate the tubular apoptosis (n = 6). Scale bars, 50 μm. C The expression of ALDH2 and KIM-1 was measured by western blotting (n = 6). D The expression of mitochondria-related proteins (PGC-1α and ATP5a1) was measured by western blotting (n = 6). E ATP levels were assessed using an ATP Assay Kit (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001, ^####P < 0.0001; ^&P < 0.05, ^&&P < 0.01, ^&&&P < 0.001, ^&&&&P < 0.0001; ns not significant. (WT Con wild-type control, KO Con knockout control, WT Cis wild-type cisplatin, KO Cis knockout cisplatin).