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. 2022 Dec 8;18(1):190–204. doi: 10.1016/j.stemcr.2022.11.006

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Transcriptomic enrichment analysis

(A) Venn diagram showing the distribution of 2,127 DEGs in adult-MSCs compared with UC-MSCs.

(B) GO enrichment analysis indicates the cellular localization of the 730 common adult-MSC DEGs.

(C) All significant (FDR < 0.05) pathways upregulated in UC-MSCs compared with adult-MSCs.

(D) Circos plot depicts the relationship between enriched immune-regulatory pathways and their corresponding genes. Clockwise from top: pathways and genes are ordered by their number of interactions. Ribbon size encodes cell value associated with row/column segment pair. Column segment value and ribbon color are decided by the number of interactions.

(E) All significant (FDR < 0.05) pathways upregulated in adult-MSCs compared with UC-MSCs.

(F) Protein network of genes involved in extracellular matrix (ECM) organization pathway identified in adult-MSCs. Yellow circles indicate ECM proteolysis enzymes (MMPs, ELANE, and PLG) identified in our genomic screen. All other significant genes identified in our screen are highlighted with a black border. No fill circles indicate genes that are not validated experimentally.