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. 2022 Dec 8;18(1):190–204. doi: 10.1016/j.stemcr.2022.11.006

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Comparison of growth factors and immune mediators in the secretome of UC-MSCs and adult-MSCs

(A) PCA and heatmap of mean fluorescent intensity (MFI) values of (A) growth factors and (B) immune mediators secreted in CM from all three MSC sources (n = 3 donors per source). Comparison of gene ratio frequency (number of genes in our screen versus all background genes associated with that pathway) between significant (FDR < 0.05) angiogenic pathways (i.e., canonical and immune modulatory) enriched in (C) UC-MSCs and (D) adult-MSCs.