Figure 6.
Comparison of immunomodulatory factors in the secretome of UC-MSCs and adult-MSCs
(A and B) PCA and heatmap of MFI values of (A) anti-inflammatory factors; and (B) immunosuppressive factors, secreted in culture media (CM) from all three MSC sources (n = 3 donors per source).
(C) Protein-protein interaction maps (PPI score >1.0 × 10−12) of 24 immunomodulatory factors were identified using the String database and ordered using the number of edges associated with each gene (degree sorted) in Cytoscape for AD-MSCs, BM-MSCs, and UC-MSCs. Genes with significant MFI values are color coded based on their anti-inflammatory (red), immunosuppressive (yellow), and anti-inflammatory/immunosuppressive dual roles (orange). Gray represents no change in MFI.