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. 2022 Dec 26;299(2):102839. doi: 10.1016/j.jbc.2022.102839

Figure 2.

Figure 2

Fractional trafficking efficiency and total expression of PMP22 WT and T118M. Histograms of WT PMP22 trafficking efficiencies in human embryonic kidney (HEK) (A) and Madin–Darby canine kidney (MDCK) (B) cells. The trafficking efficiency is the level of PMP22 on the surface over total cellular PMP22 (surface + internal), as expressed in fractional units (to convert to percent, multiply by 100). Histograms of T118M trafficking efficiencies in HEK (C) and MDCK (D) cells. E, comparison of the total T118M PMP22 expression levels in HEK and MDCK cells (Mann–Whitney tests used to compare normalized T118M expression to WT for each cell type). For the HEK cell data, n = 5 experiments with 2500 cells each. For MDCK cell data, n = 3 experiments with 2500 cells each. PMP22, peripheral myelin protein 22.