FIG. 2.

Vaginal fungal burden during primary or secondary experimental vaginitis. Mice received a primary vaginal inoculation and were allowed 4 weeks to resolve the infection, followed by a second inoculation in the presence of estrogen. Control mice that were previously naïve received a simultaneous primary inoculation in the presence of estrogen. C. albicans vaginal fungal burden was monitored over a 17-day period in mice with primary infection and a 10-day period in mice with secondary infection. Data are cumulative of four experiments using 10 to 13 mice per group. Separate mice were used for each time point. Asterisks indicate where significant decreases from results found in mice with primary infection were observed. SEM, standard error of the mean.