Fig. 5.

Human CD147 transgenic mouse model with BA.1 Omicron infection exhibited exudative alveolar inflammation. Inoculation mice via the intranasal at 3 × 10⁵ TCID₅₀ of BA.1 Omicron, and sample collected at 3 and 6 d.p.i. a RT-qPCR for viral RNA levels in the lung, nose, throat, trachea, and bronchus (n = 4). b Virions in the alveolar type II cells, neutrophils and macrophages in lung tissues of human CD147 transgenic mice (at 3 d.p.i.) were detected by electron microscopy (scale bars, 500 nm). c H&E staining of tissues sections from infected human CD147 transgenic mice (scale bars, 200 μm). d Gene expression of cytokines and chemokines in lung homogenates determined by RT-qPCR (n = 4). Data are represented as mean ± SEM, p-values were determined by two-tailed student t-test, **p < 0.01, ***p < 0.001