Fig. 6.

CD147 is a target for the treatment of COVID-19 caused by Omicron. Human CD147 transgenic mice were intranasally inoculated with 3 × 10⁵ TCID₅₀ Omicron and treated with meplazumab the next day. a RT-qPCR for viral RNA levels in lung tissues at 3 and 6 d.p.i. (n = 4). b H&E staining of lung tissue sections from the IgG and meplazumab groups at 3 and 6 d.p.i. (scale bars, 200 μm). c Gene expression of cytokines and chemokines in lung homogenates determined by RT-qPCR, compared with the corresponding IgG controls at 3 d.p.i. (top) and 6 d.p.i. (bottom) (n = 4). Gapdh was used as a reference gene. Data are represented as mean ± SEM, p-values were determined by two-tailed student t-test, *p < 0.05, **p < 0.01, ***p < 0.001