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. 2022 Dec 5;26(1):105714. doi: 10.1016/j.isci.2022.105714

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© 2022.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Simulated and experimentally found proliferation pattern in a pilot experiment in pig

(A) Bright-field micrograph of pig liver t = 2 days after PHx (Red = Central veins detected by image processing and analysis, Blue = portal veins; height of sample: 3.5 mm, width: 2.5 mm).

(B) Predicted proliferation scenario in pig during first proliferation wave (t = 1 day) and C) after t = 2 days.

(D) PCNA stained micrograph (whole slide scan) of a part of a pig liver 14 days after PHx. Proliferation is mainly localized near the Glisson capsule (orange arrow).

(E) (Lower left) Quantification of proliferation within the lobe in relation to the distance to the Glisson capsule.

(F) Quantification of proliferation within the lobule shows increased periportal proliferation. (G and H) Proliferation pattern in further pig livers (2 days after PHx). This experimental data also indicates possible increased proliferation near the Glisson capsule (orange/red arrows).