Table 3.

Net reclassification index considering competing events for risk reclassification of recurrence (events) and non-recurrence (non-events).

	Overall NRI	Z value	p value	Up events relative change in sensitivity (95% CI)	Up non-events relative change in specificity (95% CI)
AFP score vs.				29.0%	91.7%
Up-to 7 + AFP <200	-0.033	−1.52	0.064	−8.5%	+5.1%
Up-to 5 + AFP <400	-0.006	−0.21	0.41	−22.5%	+21.8%
Up-to 4 + AFP <1,000	0.023	0.59	0.72	−42.0%	+44.4%

All models assessed at listing. The NRI was estimated to evaluate the ability of these models to discriminate between events and non-events by quantifying the agreement between “upward” and “downward” risk reclassifications and event status.^12,13 Level of significance, p value <0.05.

AFP, alpha-fetoprotein; NRI, net reclassification index.