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. 2022 Dec 30;26(1):105909. doi: 10.1016/j.isci.2022.105909

Figure 2.

Figure 2

Knockout of PKR delays vascular aging

(A) H&E staining of aorta tissues in WT and PKR knockout mice of different age.

(B) Masson staining of aorta tissues in WT and PKR knockout mice of different age.

(C) Morphometry analysis quantifying intima and media thickness, collagen area and elastin area in the aorta tissues from WT and PKR knockout mice of different age. Data are represented as mean ± SEM.

(D) Representative photomicrographs and statistical analysis of serial sections of arteries from WT and PKR knockout mice of different age (n = 5). Sections were immunohistochemical stained for p16 (n = 5). Data are represented as mean ± SEM and Scale Bar = 50 μm.

(E) Representative photomicrographs and statistical analysis of serial sections of arteries from WT and PKR knockout mice of different age (n = 5). Sections were immunohistochemical stained for p53 (n = 5). Data are represented as mean ± SEM and Scale Bar = 50 μm.

(F) Representative photomicrographs of blood flow density imaged by laser Doppler in the lower limb of WT and PKR knockout mice of different age.

(G) Statistical analysis of blood flow density in the lower limb from WT and PKR knockout mice of different ages. Data are represented as mean ± SEM. ∗∗p< 0.01; ∗∗∗p< 0.001; #p< 0.05; ##p< 0.01 (two-way ANOVA test).