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. 2022 Dec 30;26(1):105909. doi: 10.1016/j.isci.2022.105909

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Silencing endothelial PKR inhibits palmitic acid-induced endothelial cell hyperactivation and phenotypic transformation of vascular smooth muscle

(A) Representative immunoblots and densitometric analysis of GSDMD, N-GSDMD, PKR and p-PKR level in siCon and PKR knockdown (siPKR) HUVECs stimulated with palmitic acid (n = 3).

(B) LDH assay in the supernatants of siCon and PKR knockdown (siPKR) HUVECs stimulated with palmitic acid (n = 3).

(C) Representative immunoblots and densitometric analysis of α-SMA, SM22α, caldesmon, calponin, thrombospondin and osteopontin level in HASMCs that co-cultured with indicated HUVECs (n = 3). ^∗p< 0.05; ^∗∗p< 0.01; ^∗∗∗p< 0.001 (two-way ANOVA test). Data are represented as mean ± SEM.