Table 1.
Effects of thymoquinone (2.5, 5 and 10 mg/kg) treatment on the acute and delayed phase of nociception induced by formalin in neuropathic mice.
| Treatment (n = 5) | Dose | Acute Phase | Delayed Phase | ||
|---|---|---|---|---|---|
| No. of Flinches | Licking Duration (Sec) | No. of Flinches | Licking Duration (Sec) | ||
| Vehicle | 10 mL/kg, p.o. | 4.4 ± 0.812 | 44.2 ± 8.49 | 1.4 ± 0.509 | 11.82 ± 3.251 |
| Vincristine | 0.1 mg/kg, sc | 161.0 ± 4.701 ### | 254.29 ± 27.55 ### | 38.2 ± 6.98 ### | 34.47 ± 2.741 ### |
| TQ 2.5 | 2.5 mg/kg, p.o. | 134.8 ± 9.521 ### | 226.76 ± 18.81 ### | 21.4 ± 5.202 #,* | 23.96 ± 1.172 ##,* |
| TQ 5 | 5 mg/kg, p.o. | 106.2 ± 4.454 ###,** | 172.9 ± 18.50 ###,* | 19.0 ± 2.51 #,* | 20.21 ± 0.785 *** |
| TQ 10 | 10 mg/kg, p.o. | 80.8 ± 5.544 ###,*** | 147.43 ± 8.03 ##,** | 12.4 ± 2.315 *** | 14.32 ± 1.261 *** |
| PGB | 10 mg/kg, p.o. | 78.0 ± 17.595 ###,*** | 142.77 ± 18.08 ##,** | 8.4 ± 1.887 *** | 12.14 ± 1.599 *** |
| Per se | 10 mg/kg, p.o. | 80.0 ± 5.568 ###,*** | 132.2 ± 16.18 #,*** | 5.6 ± 1.965 *** | 16.14 ± 2.018 *** |
All the data are represented as mean ± SEM. Vincristine (VCR) was injected by intraperitoneal (i.p.) route, while thymoquinone (TQ) by oral route (p.o.). The duration of treatment lasted for 14 days. VCR was administered for 10 consecutive days. n, number of animals; Vehicle, 2.5% DMSO; TQ, Thymoquinone; PGB, Pregabalin. # p < 0.05, ## p < 0.01, ### p < 0.001 vs. Group I (vehicle). * p < 0.05, ** p < 0.01, *** p < 0.001, vs. Group II (Pathogenic control), considered significant by ANOVA followed by Tukey-Kramer multiple comparison test.