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. 2023 Jan 7;59(1):120. doi: 10.3390/medicina59010120

Figure 1.

Figure 1

Fold change (FC) of 28 analytes in monocytes and CD4+ lymphocytes at baseline between lithium responders and non-responders. Note: FC = log2 (median fluorescent ratio of non-responders/median fluorescent ratio of responders). Positive value is indicative of a higher level of protein expression in lithium non-responders than in lithium responders. Negative value is indicative of a lower level of protein expression in lithium non-responders than in lithium responders. Abbreviations: BAK: BAX, BCL2-Associated × Protein; BCL-2: B-cell lymphoma 2; BCL-2 A1: Bcl-2-related protein A1; BDNF: brain-derived neurotrophic factor; Calmodulin: calciummodulated protein; Fyn: a tyrosine kinase belongs to the Src family of tyrosine kinases including src, fyn, and yes; GSK3β: glycogen synthase kinase 3 beta; HMGB1: High mobility group box 1 protein; iNOS: inducible isoform nitric oxide synthases; IRS2: Insulin receptor substrate 2; MARCKS: myristoylated alaninerich C-kinase substrate; mTor: mammalian target of rapamycin; NLRP3: NACHT, LRR and PYD domains-containing protein 3; NR3C1: nuclear receptor subfamily 3, group C, member 1; phospho-CREB: phosphorylated cAMP response element-binding protein (Ser133); phospho-Fyn/Yes: phosphorylated Fyn(Y530)/Yes(Y537); phospho-GSK3αβ: phosphorylated glycogen synthase kinase 3 alpha(Tyr279) beta(Tyr216); phospho-GSK 3β: phospho-glycogen synthase kinase 3 beta(Tyr216); phospho-NFkB-P65: phosphorylated nuclear factor NF-kappa-B p65(Ser536) subunit; PDEB4: cAMP-specific 3′,5′-cyclic phosphodiesterase 4B; PGM1: phosphoglucomutase 1; PKA C-α: protein kinase A catalytic subunit; PKC-θ: protein kinase C theta; PPAR-γ: peroxisome proliferator-activated receptor gamma; Timeless: a protein is necessary of proper functioning of circadian rhythm; TNFAIP3: tumor necrosis factor, alpha-induced protein 3; TPH1: tryptophan hydroxylase 1; XBP1: X-box binding protein 1.