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Schematic illustration of the components in a liquid biopsy. Liquid biopsy obtained from peripheral blood contains different tumor-associated materials such as circulating tumor cells (CTCs), circulating tumor DNA (cfDNA), extracellular vesicles (EVs), free histones, and histone complexes. Such fractions can be isolated and analyzed for tumor-specific aberrations at the genomic, transcriptomic, proteomic, and metabolomic levels. Figure created with BioRender.com.
