Table 4.
Significant differences in anthropometric, biochemical/hormonal parameters, IR, and liver fibrosis indices between PCOS adolescents with or without hepatic steatosis.
| HSI ≤ 36 (n = 26) |
HSI > 36 (n = 18) |
p-Value | |
|---|---|---|---|
| BMI (kg/m2) | 22.33 ± 3.09 | 30.69 ± 3.98 | <0.001 |
| Waist circumference (cm) | 70.80 ± 5.53 | 85.31 ± 9.22 | <0.001 |
| Hip circumference (cm) | 96.82 ± 7.06 | 111.03 ± 8.86 | <0.001 |
| Waist to height ratio | 0.44 ± 0.04 | 0.53 ± 0.06 | <0.001 |
| Waist to hip ratio | 0.73 ± 0.45 | 0.77 ± 0.06 | 0.030 |
| SBP (mmHg) | 113.57 ± 8.93 | 121.06 ± 11.05 | 0.025 |
| FAI § | 3.05 (3.48) | 5.31 (5.69) | 0.034 |
| Insulin (μU/mL) § | 9.40 (3.75) | 15.00 (6.40) | 0.001 |
| QUICKI | 0.34 ± 0.02 | 0.32 ± 0.02 | 0.002 |
| HOMA-IR § | 2.02 (0.89) | 3.16 (2.03) | 0.002 |
| G/I ratio | 9.34 ± 3.33 | 5.88 ± 2.42 | 0.001 |
| Total cholesterol (mg/dL) | 143.12 ± 18.44 | 159.27 ± 29.49 | 0.031 |
| LDLc (mg/dL) | 77.56 ± 20.21 | 94.07 ± 29.08 | 0.031 |
| Triglycerides § (mg/dL) | 51.50 (30.90) | 75.00 (31.00) | 0.019 |
| Fibroscan® stiffness (kPa) | 5.30 ± 1.30 | 7.37 ± 0.99 | 0.009 |
Abbreviations: IR, insulin resistance; PCOS, polycystic ovary syndrome; HSI, hepatic steatosis index; BMI, body mass index; SBP, systolic blood pressure; FAI, free androgen index; QUICKI, quantitative insulin sensitivity check index; HOMA-IR, homeostatic model assessment for insulin resistance; G/I ratio, glucose to insulin ratio; LDLc, low-density lipoprotein cholesterol. Values refer to mean ± standard deviation and t-test or § median (interquartile range) and Mann–Whitney U. Bold indicate statistically significant differences.