Figure 2.

Plasminogen binding and activation on the membrane of mouse cortical neurons. (A) Kinetics of plasmin formation on the cell membrane upon incubation with a fixed amount of plasminogen. (B) Plasminogen binds to membrane receptors in a concentration-dependent manner and is converted to plasmin until saturation. The specificity of plasminogen binding to the terminal lysine residues of membrane receptors is confirmed by its inhibition in the presence of the lysine analogue ε-aminocaproic acid, ε-ACA (inset) [42,49,50].