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. 2023 Jan 3;16(1):72. doi: 10.3390/ph16010072

Table 5.

NAC stability study, 25 ± 2 °C ambient storage conditions.

T0 6 h 1 Day 2 Days 3 Days 4 Days 7 Days 8 Days R 2,4 p Value 5
NAC content ± S.D. 1 22.82 ± 1.99 22.15 ± 0.17 21.78 ± 0.26 22.03 ± 0.43 21.52 ± 0.29 21.95 ± 0.25 21.61 ± 0.42 21.27 ± 0.20 0.58 <0.05
% NAC dimer ± S.D. 2 0.20 ± 0.03 0.29 ± 0.01 0.39 ± 0.02 0.52 ± 0.01 0.61 ± 0.01 0.71 ± 0.02 1.09 ± 0.10 1.13 ± 0.18 0.99 <0.001
Osmolality 3 511 508 507 507 505 521 515 520 0.48 NS 6
pH 6.26 6.13 6.11 6.04 6.05 6.04 6.04 5.95 0.65 <0.02
Visible particles none none none none none none none none

1 expressed as the mean value of triplicate analysis, in mg·mL−1; 2 expressed as the mean value of triplicate analysis; 3 expressed in mOsm.kg−1; 4 coefficient of determination; 5 correlation coefficient test significance; 6 not statistically significant.