Table 7.
NAC + 62.5 µg·mL−1 zinc gluconate stability study, 5 ± 3 °C storage conditions.
| T0 | 1 Day | 2 Days | 3 Days | 4 Days | 7 Days | 8 Days | R 2,4 | p Value 5 | |
|---|---|---|---|---|---|---|---|---|---|
| NAC content ± S.D. 1 | 21.78 ± 0.20 | 21.97 ± 0.43 | 22.33 ± 0.60 | 22.42 ± 0.61 | 22.17 ± 0.10 | 22.57 ± 0.13 | 23.25 ± 0.05 | 0.80 | <0.01 |
| % NAC dimer ± S.D. 2 | 0.28 ± 0.03 | 0.28 ± 0.03 | 0.30 ± 0.04 | 0.32 ± 0.03 | 0.34 ± 0.01 | 0.36 ± 0.01 | 0.36 ± 0.01 | 0.92 | <0.001 |
| Osmolality 3 | 499 | 512 | 505 | 502 | 526 | 522 | 484 | 0.01 | NS 6 |
| pH | 5.22 | 5.14 | 5.19 | 5.19 | 5.21 | 5.14 | 5.20 | 0.03 | NS 6 |
| Sterility | Sterile | ND | ND | ND | Sterile | ND | Sterile | ||
| Endotoxins 4 | 0.1< | ND | ND | ND | 0.1< | ND | 0.1< | ||
| Visible particles | none | none | none | none | none | none | none |
1 expressed as the mean value of triplicate analysis, in mg·mL−1; 2 expressed as the mean value of triplicate analysis; 3 expressed in mOsm.kg−1; 4 expressed in IU.mL−1; 4 coefficient of determination; 5 correlation coefficient test significance; 6 not statistically significant.