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Multiple signaling pathways of leptin and its downstream effectors. ObRb oligomerization (for the clarity of the figure, only dimerization it is shown) activates JAK2/STAT3, PI3K, and ERK pathways. Activated JAK2 kinase induces Tyr residues of ObRb, that activates STAT-3 and -5. ObRb phosphorylation recruits SHP2 and Grb2 and increases ERK signaling. Crosstalk of leptin and insulin signaling is represented by the shaded area. See Section 2.1 for details.
