Table 1.
Summary of diagnostic accuracy of ctDNA assay for CRC in multiple subgroups.
| Group | SEN (95% CI) | SPE (95% CI) | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | AUC |
|---|---|---|---|---|---|---|
| Quantitative analysis of ctDNA | 0.723 (0.623–0.803) | 0.920 (0.827–0.966) | 6.820 (3.335–12.800) | 0.326 (0.227–0.446) | 23.305 (9.378–57.906) | 0.860 |
| Qualitative analysis of ctDNA | 0.609 (0.563–0.650) | 0.891 (0.864–0.910) | 4.960 (4.190–5.860) | 0.453 (0.406–0.498) | 12.621 (10.004–15.922) | 0.828 |
| SEPT9 methylation assay | 0.679 (0.622–0.732) | 0.904 (0.881–0.923) | 6.420 (5.110–7.970) | 0.367 (0.307–0.430) | 20.551 (14.684–28.760) | 0.883 |
Abbreviations: 95% CI, 95% confidence interval; AUC, the area under the curve; CRC, colorectal cancer; ctDNA, circulating tumor DNA; DOR, diagnostic odds ratio; NLR, negative likelihood ratio; PLR, positive likelihood ratio; SEN, sensitivity; SPE, specificity.