Table 1.

Determinants of integration site selection of MLV and HIV-1. Bromodomain (BD); bromodomain and extra terminal motif (BET); catalytical core domain (CCD); cleavage and polyadenylation specificity factor 6 (CPSF6); C-terminal domain (CTD); extra-terminal domain (ET); hepatoma-derived growth factor-related protein 2 (HRP2); integrase-binding domain (IBD); integrase (IN); lens epithelium-derived growth factor (LEDGF/p75); nucleoporin 153 (Nup153); pre-integration complex (PIC); ran–binding protein 2 (RanBP2); transportin SR2 (TRN-SR2). (Table created with Biorender.com on 17 December 2022).

Host Factors and Viral Proteins Involved in Nuclear Import and/or MLV Integration Site Selection
Host Factor	Viral Protein	Description	References
p12	/	Tether of PIC to mitotic chromosomes	[46,47,48,49,50]
BET	/	BD binds viral IN, ET binds chromatin	[28,29,30,31,32,33,34,51,52,53,54,55,56,57]
/	IN	CCD and CTD bind target DNA	[30,51,53,58,59]
Host Factors and Viral Proteins Involved in Nuclear Import and/or HIV-1 Integration Site Selection
Host Factor	Viral Protein	Description	References
TRN–SR2	/	Karyopherin involved in nuclear import	[60]
RanBP2	/	Nuclear pore protein involved in Nuclear import	[60]
Nup153	/	Karyopherin involved in nuclear import	[61,62]
CPSF6	/	Nuclear import factor binding to HIV-1 capsid	[63,64,65,66,67]
LEDGF/p75	/	IBD binds viral IN, PWWP domain binds H3K36me2/3	[22,23,35,36,37,38,39,40,41,42,45,52,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87]
HRP2	/	IBD binds viral IN, PWWP domain binds H3K36me2/3	[74]
/	IN	CCD and CTD bind target DNA	[88,89,90,91,92,93,94,95,96,97,98]