Table 2.
Determinants of retroviral integration site selection. Avian sarcoma-leukosis virus (ASLV); bromodomain and extra terminal motif (BET); bovine leukemia virus (BLV); facilitates chromatin transcription complex (FACT complex); feline immunodeficiency virus (FIV); group–specific antigen (Gag); human immunodeficiency virus type 1 (HIV-1); human immunodeficiency virus type 2 (HIV-2); human T lymphotropic virus type 1 (HTLV-1); human T lymphotropic virus type 2 (HTLV-2); integrase (IN); lens epithelium–derived growth factor (LEDGF/p75); mouse mammary tumor virus (MMTV); murine leukemia virus (MLV); protein phosphatase 2A (PP2A); Rous sarcoma virus (RSV); simian immunodeficiency virus (SIV). (Table created with Biorender.com on 17 December 2022).
| Retroviral Integration Site Selection | |||||
|---|---|---|---|---|---|
| Retrovirus | Classification | Classification | Host Factor | Viral Protein | References |
| ASLV | ortho-retroverinae | alpharetrovirus | Unknown (FACT complex?) | / | [5,6,7,99,100,101] |
| RSV | alpharetrovirus | Unknown (FACT complex?) | IN | [8,102,103,104,105] | |
| MMTV | betaretrovirus | / | / | [9,10,11,106,107,108] | |
| MLV | gammaretrovirus | BET proteins | IN | see Table 1 | |
| HTLV-1 | deltaretrovirus | PP2A | / | [13,109,110,111,112,113,114,115,116,117,118,119,120] | |
| HTLV-2 | deltaretrovirus | PP2A | / | [14,120] | |
| BLV | deltaretrovirus | PP2A | / | [15,16,17,18,19,121] | |
| HIV-1 | lentiretrovirus | LEDGF/p75 | IN | see Table 1 | |
| HIV-2 | Lentiretrovirus | LEDGF/p75 | / | [122,123,124,125,126,127] | |
| SIV | Lentiretrovirus | LEDGF/p75 | IN | [24,128,129] | |
| FIV | lentiretrovirus | LEDGF/p75 | / | [25,37] | |
| Humanfoamy virus | Spuma-retrovirinae | / | Gag | [26,27,49,130,131,132,133] | |