Table 1.
Sample characteristics (n = 1806) for the investigated TREND-0 sample.
| Females (n = 955) | Males (n = 851) | Comparison | |
|---|---|---|---|
| Age | 50.6 (13.5), [21–81] | 50.4 (14.3), [21–81] | T = −0.23, p = 0.82 |
| Education | χ2 = 23.5, p < 0.001 | ||
| <10 years | 139 (14.6%) | 115 (13.5%) | |
| =10 years | 567 (59.4%) | 425 (49.9%) | |
| >10 years | 249 (26.0%) | 311 (36.6%) | |
| Hippocampal volume in cm3 | 6.6 (0.57), [4.5–8.3] | 7.2 (0.67), [5.0–9.7] | T = 20.7, p < 0.001 |
| ICV in cm3 | 1496 (116), [1054–1914] | 1693 (131), [1314–2135] | T = 33.8, p < 0.001 |
| MDD lifetime (yes) | 219 (22.9%) | 106 (12.5%) | χ2 = 33.9, p < 0.001 |
| Missing | 8 (0.8%) | 4 (0.5%) | |
| PHQ-9 sum score | 4.3 (3.68), [0–25] | 3.2 (3.36), [0–26] | T = −6.2, p < 0.001 |
| Missing | 66 (6.9%) | 53 (6.2%) | |
| Immediate verbal memory score | 5.54 (1.26), [0–8] | 5.25 (1.22), [0–8] | T = −5.07, p < 0.001 |
| Delayed verbal memory score | 6.03 (1.59), [−3–8] | 5.51 (1.68), [–1, 8] | T = −6.82, p < 0.001 |
| Missing | 6 (0.6%) | 9 (1.1%) | |
| APOE ε4 status | χ2 = 0.48, p = 0.49 | ||
| ε4 allele carrier | 217 (22.7) | 204 (24.0%) | |
| missing | 22 (2.3%) | 24 (2.8%) | |
| 5-HTTLPR | χ2 = 1.99, p = 0.37 | ||
| SS | 202 (21.2%) | 159 (18.7%) | |
| SL | 439 (46.0%) | 395 (46.4%) | |
| LL | 224 (23.5%) | 215 (25.3%) | |
| Missing | 90 (9.4%) | 82 (9.6%) | |
| COMT Val158Met | χ2 = 2.83, p = 0.24 | ||
| GG (Val/Val) | 254 (26.6%) | 252 (29.6%) | |
| GA (Val/Met) | 505 (52.9%) | 418 (49.1%) | |
| AA (Met/Met) | 196 (20.5%) | 181 (21.3%) | |
| BDNF Val66Met | χ2 = 3.68, p = 0.16 | ||
| AA (Met/Met) | 36 (3.8%) | 41 (4.8%) | |
| GA (Val/Met) | 274 (28.7%) | 270 (31.7%) | |
| GG (Val/Val) | 645 (67.5%) | 540 (63.5%) | |
| KIBRA rs17070145 | χ2 = 0.60, p = 0.74 | ||
| TT | 105 (11.0%) | 92 (10.8%) | |
| CT | 416 (43.6%) | 357 (42.0%) | |
| CC | 434 (45.4%) | 402 (47.2%) |
Full sample characteristics for the main analyses on the association between genetic variants and hippocampal subfields. Metric variables are displayed as mean (standard deviation) and range, categorical variables as count/number (percentage). ICV, intracranial volume; MDD, major depressive disorder; PHQ-9, Patient Health Questionnaire. The t-tests and χ2 tests were calculated on non-missing data.