Table 2.

Association results for the direct effects of candidate genetic variants and polygenic risk score for Alzheimer’s disease (PRS AD) on hippocampal volume and its subfield volumes in TREND-0 (n = 1806).

HC Volume	APOE	5-HTTLPR	BDNF	COMT	KIBRA	PRS AD
Whole HC	0.010(−)	0.017(−)	0.038(−)	0.180 (−)	0.370 (−)	0.564 (−)
CA1	0.003(−)	0.032(−)	0.310 (−)	0.200 (−)	0.540 (−)	0.450 (−)
CA3	0.110 (−)	0.026(−)	0.640 (+)	0.440 (−)	0.680 (+)	0.346 (+)
CA4	0.071 (−)	0.034(−)	0.210 (−)	0.410 (−)	0.390 (−)	0.800 (+)
Presubiculum	0.450 (−)	0.740 (−)	0.014(−)	0.480 (−)	0.580 (−)	0.208 (−)
Subiculum	0.190 (−)	0.400 (−)	0.025(−)	0.500 (−)	0.230 (−)	0.347 (−)
Parasubiculum	0.770 (+)	0.740 (+)	0.170 (−)	0.910 (−)	0.560 (−)	0.742 (+)
Molecular layer DG	0.014(−)	0.019(−)	0.084 (−)	0.210 (−)	0.500 (−)	0.555 (−)
Granule layer DG	0.028(−)	0.020(−)	0.140 (−)	0.320 (−)	0.500 (−)	0.911 (−)
HC tail	0.046(−)	0.009(−)	0.032(−)	0.210 (−)	0.170 (−)	0.926 (−)
Fimbria	0.350 (−)	0.670 (−)	0.910 (−)	0.960 (+)	0.180 (+)	0.327 (−)
Fissure	0.790 (+)	0.810 (+)	0.400 (+)	0.580 (+)	0.520 (−)	0.351 (+)
HATA	0.033(−)	0.510 (−)	0.840 (−)	0.500 (−)	0.640 (+)	0.539 (−)

The p-values and effect directions (in brackets; positive + and negative −) are presented, significant results are displayed in bold. Analyses were adjusted for age, sex, intracranial volume, educational attainment, three genetic PCs, and genetic batch. Coding alleles: 5-HTTLPR = L allele, APOE = ε4 allele, BDNF = Val allele, COMT = Met allele, KIBRA = C allele. HC, hippocampus; CA, cornu ammonis; DG, dentate gyrus; HATA, hippocampus–amygdala transition area.