Table 4.

Experimental data for binding of SalA and all analogs discussed within this section measured in radioligand binding assays.

Ligand	Affinity (Ki) [nM]	Ki [ligand]/Ki [SalA]	Reference
2 (SalB)	155 ± 23 c	119	[38]
	>10,000 a	-	[72]
	111 ± 12 c	85	[71]
	155 ± 23 c	119	[73]
	280 ± 20 d	147	[47]
	>10,000 b	-	[68]
3	>10,000 a	-	[72]
4	>10,000 a	-	[72]
	>10,000 c	-	[71]
5	17.6 ± 3.1 c	14	[73]
6	0.32 ± 0.02 c	0.133	[69]
	3.13 ± 0.40 b	0.423	[70]
7 (RB-64)	0.59 ± 0.21 b	0.328	[55]
	39 ± 11 c	2	[55]
	0.6 ± 0.2 b	0.097	[68]
8	>10,000 c	-	[74]
	>1000 c	-	[58]
	>1000 c	-	[59]
9	>10,000 c	-	[73]
10	28.5 ± 0.9 c	22	[58]
11	>1000 c	-	[58]
12	3400 ± 150 d	1789	[42]
13	55 ± 23 c	22	[41]
14	40 ± 1 b	5	[75]
15	2.9 ± 0.3 c	1	[41]
	3.0 ± 0.2 d	2	[42]
16	>8000 b	-	[76]
17	6 ± 1 b	2	[77]
18	18 ± 2 b	5	[77]
19	1125 ± 365 b	281	[77]

^a K_i determined against [³H]bremazocine. ^b K_i determined against [³H]U69,593. ^c K_i determined against [³H]diprenorphine. ^d K_i determined against [¹²⁵I]IOXY.