Table 1.

Major outbreaks of HFMD and their causes.

Virus	Asia				Others
EV71	Area	Year	Number Infected		Area	Year	Number Infected
	Malaysia	1997	41	[9]	California	1974	UNKNOWN	[10]
	China	2008–2012	>7 million	[11]	Bulgarian	1975	700	[12]
	Singapore	2008	29686	[13]	Hungary	2000	UNKNOWN	[14]
	Taiwan	1998	1.5 million	[15]	Austria	2002	12	[16]
	Japan	2010	2900	[17]	Holland	2007	58	[18]
	Vietnam	2005	173	[19]	Denmark	2007	29	[20]
	Russia	2013	UNKNOWN	[21]	Marseille, France	2009	3	[22]
CVB3	Hong Kong	2008	<100	[23]	Poland	1999–2014	<55	[24]
	India	2009–2010	15	[25]
	Hebei, China	2010–2012	26	[26]
	Shandong, China	2016	42	[27]
CVA16	Shanghai, China	2014–2016	144	[28]	Toronto	1957	<100	[29]
					Birmingham	1959	24	[30]
					USA	1959	UNKNOWN	[31]
					Germany	2006	<500	[32]
CVA6	India	2009–2010	<89	[33]	Finland	2008	<50	[34]
	GZ, China	2010–2012	720	[35]	France	2010	25	[36]
	BJ, China	2015	<56	[37]	Spain	2010–2012	<30	[38]
	Thailand	2012	<600	[39]
CVA10	Japan	1981–1982	18	[40]	USA	1950/2016	UNKNOWN	[40]
	Tajikistan	2004	UNKNOWN	[40]	Germany	2003	UNKNOWN	[40]
	China	2004–2008	>1000	[40]	France	2010	<100	[40]
	Russia	2004–2013	UNKNOWN	[40]	Chad	2006	UNKNOWN	[40]
	Singapore	2008	<100	[40]	Austria	2007	UNKNOWN	[40]
					Spain	2008	UNKNOWN	[40]
					Central African Republic	2008	UNKNOWN	[40]
CVB1	India	2007	UNKNOWN	[41]	USA	2006–2008	235	[42]
	Korea	2008	>104	[43]	Spain	2008	<100	[44]
	Taiwan	2008–2010	>22	[41]
CVB2	Jiangsu, China	2009	<111	[45]	São Paulo State, Brazil	2004	<10	[46]
	Cambodia	2012	<50	[47]
	Thailand	2016	<20	[48]
CVA4	Taiwan	2004–2006	UNKNOWN	[49]	USA	1950	UNKNOWN	[49]
	BJ, China	2011	21	[50]
	Hangzhou, China	2016	3	[51]
CVB5	Shandong, China	2005	>54	[52]	Thuringia, Germany	2010	<7	[53]
	Zhejiang, China	2013	<92	[54]	Chiba Prefecture, Japan	2016	3	[55]
CVA9	Gansu, China	2005	<85	[56]	Alberta, Canada	2010	174	[57]
					Mossel Bay, South Africa	Dec 2015–Jan 2016	>26	[58]