Table 1.

Examples of various nucleic acid-based micelles for cancer therapy.

Nucleic Acid	Hydrophobic Moiety	Size (nm)	Therapeutic Agent	Therapy	Cell or Tumor Type	Ref.
DNA	Diacyl chain	68 ± 13	TDO5 aptamer	Cancer targeting	Ramos cells	[51]
DNA	Diacyl lipid	17 ± 2	sgc8 aptamer	Cancer targeting	CCRF-CEM cells	[52]
DNA	PPO	10.8 ± 2.2	Doxorubicin (Dox), Folic acid (FA)	Chemotherapy Cancer targeting	Caco-2 cells	[45]
DNA	Dodecane	11.8 ± 0.4	BKM120	Chemotherapy	HeLa cells	[53]
DNA	Cholesterol	371.3 ± 3.1	DOX, anti-MUC1, KLA peptide	Chemotherapy Cancer targeting	MCF-7 cells, C26-tumor	[39]
DNA	CPT	32 ± 13	CPT	Chemotherapy	SK-BR-3 cells	[28]
RNA	Cholesterol	118.7 ± 14.50	Paclitaxel (PTX)	Chemotherapy	Human KB cells, KB tumor	[46]
DNA	Octadecyl chain	43	Fluorouracil	Chemotherapy	HeLa cells	[54]
DNA	DPPE lipid	25 ± 5	ODN 1826, ODN 7909	Immunotherapy	HEK-Blue™-mTLR9 cells, Ramos-Blue cells	[35]
DNA	Dodec-1-ynyl uracil	10.10 ± 0.68	ODN 1826, OVA antigen	Immunotherapy	B16-OVA cells, B16 melanoma, CT-26 carcinoma	[55]
RNA	Cholesterol	21.51 ± 6.136	anti-miR21, folate	Gene silencing therapy Cancer targeting	KB cells, HT29 cells, KB tumor	[56]
RNA	poly(N-isopropylacrylamide)	40~150	siPLK1, temozolomide (TMZ)	Gene silencing therapy Chemotherapy	U87MG cells, U251 cells	[49]