Figure 9.
The results of biospecific detection of miRNAs isolated from blood plasma samples. Experimental conditions: SOI-NW chip with n-type conductivity; nanowires with immobilized oDNA probes: probe_1 (a), probe_2 (b), and probe_3 (c); 1 mM PPMB; Vg = 50 V, Vds = 0.2 V; liquid volume in the measuring cell was 107 µL. Analyzed samples: samples No. 8, No. 10, No. 14, and No. 15 isolated from blood plasma of patients with ovarian cancer (olive, purple, orange, and red curves without markers); control sample No. 80 isolated from the plasma sample collected from a patient with breast cancer (blue curve, triangles); control samples No. 1 and No. 2 isolated from plasma samples collected from healthy volunteers (black curve, circles and pink curve, squares, respectively). The arrow indicates the time point when the analyzed solution containing isolated miRNAs was added.