Table 2.
Clinical, functional, and HRCT characteristics of ILD patients without PF and with PF and PPF.
| Value | ILD without PF | ILD with PF | ILD with PPF | p # | p ## |
|---|---|---|---|---|---|
| Number, n | 166 | 104 | 62 | ||
| Age, years | 55 (42;65) | 64 (55;70) | 64 (56;73) | <0.001 | 0.71 |
| Male, n (%) | 59 (35.5) | 53 (51.0) | 36 (58.1) | 0.01 | 0.32 |
| Symptoms | |||||
| Dyspnea, n (%) | 113 (68.1) | 100 (96.2) | 62 (100.0) | <0.001 | 0.96 |
| mMRC dyspnea, points | 2 (1;2) | 3 (2;3) | 3 (2;3) | <0.001 | 0.79 |
| Cough, n (%) | 120 (72.3) | 97 (93.3) | 59 (95.2) | <0.001 | 0.91 |
| Weight loss, n (%) | 28 (16.8) | 33 (31.7) | 27 (43.5) | 0.004 | 0.10 |
| Clubbing, n (%) | 6 (3.6) | 23 (22.1) | 20 (32.2) | <0.001 | 0.10 |
| Velcro crackles, n (%) | 31 (18.6) | 84 (80.8) | 53 (85.5) | <0.001 | 0.13 |
| Functional characteristics | |||||
| SpO2, % | 97 (95;98) | 95 (92;97) | 94 (92;96) | <0.001 | 0.31 |
| FVC, % predicted | 88 (73;101) | 69 (58;87) | 63 (52;76) | <0.001 | 0.08 |
| HRCT patterns | |||||
| Honeycombing, n (%) | 0 | 57 (54.8) | 37 (59.7) | <0.001 | 0.74 |
| Traction bronchiectasis, n (%) | 0 | 69 (63.5) | 43 (69.4) | <0.001 | 0.67 |
| Reticular changes, n (%) | 75 (45.2) | 99 (95.2) | 59 (95.2) | <0.001 | 0.96 |
| Ground-glass opacity, n (%) | 58 (34.9) | 40 (38.5) | 23 (37.1) | 0.56 | 0.93 |
| Consolidation, n (%) | 51 (30.7) | 13 (12.5) | 9 (14.5) | <0.001 | 0.89 |
| Basal predominance, n (%) | 28 (16.9) | 63 (60.6) | 39 (62.9) | <0.001 | 0.88 |
| Course and outcome | |||||
| Time from the onset of symptoms to diagnosis, months | 6 (2;24) | 24 (7;48) | 30 (12;40) | <0.001 | 0.88 |
| Time from the first symptom to death, months | 47 (26;65) | 48 (27;72) | 40 (21;62) | 0.62 | 0.55 |
| Death, n (%) | 19 (11.4) | 47 (45.2) | 37 (59.8) | <0.001 | 0.05 |
ILD—interstitial lung diseases; PF—pulmonary fibrosis; PPF—progressive pulmonary fibrosis; mMRC—modified Medical Research Council; SpO2—oxygen saturation of the blood; FVC—forced vital capacity; HRCT—high-resolution computed tomography. # p values compare ILD without PF and with PF. ## p values compare ILD with PF and with PPF.