Table 1.
Demographic features, radiological data, respiratory functional parameters, and BAL cellular analysis among IPF, LC-IPF and healthy subjects. FVC: forced vital capacity; FEV1: forced expiratory volume in the first second; DLCO: diffusion lung capacity for carbon monoxide; KCO: approximately kCO/barometric pressure in mL/minute/mmHg/L; HRCT: high resolution computed tomography; PFT: pulmonary function test.
| Parameters | IPF | LC-IPF | Healthy Controls | p-Value |
|---|---|---|---|---|
| N° | 23 | 7 | 15 | |
| Age (yrs) | 75 ± 6.1 | 63 ± 9 | 54.3 ± 12.9 | 0.0010 |
| Male gender (%) | 17 | 6 | 5 | 0.177 |
| Smoking status | ||||
| - Current | 0 | 0 | 1 | 0.854 |
| - Former | 12 | 3 | 4 | |
| - Never | 11 | 4 | 10 | |
| HRCT pattern | ||||
| - UIP | 20 | 6 | n.a | 0.954 |
| - Probable UIP | 3 | 1 | n.a | |
| PFTs | ||||
| - FVC (mL) | 2482 ± 804.2 | 2505 ± 688 | n.a | 0.8611 |
| - FVC (% p.v.) | 75.6 ± 18.6 | 63.5 ± 15.8 | n.a | 0.1994 |
| - FEV1 (mL) | 1952 ± 712.1 | 1920 ± 420.9 | n.a | 0.8013 |
| - FEV1 (% p.v.) | 78 ± 21.4 | 64.3 ± 17.4 | n.a | 0.179 |
| - DLCO (% p.v.) | 49.1 ± 21.4 | 36.3 ± 13.5 | n.a | 0.2772 |
| - KCO (% p.v.) | 89.4 ± 24.8 | 68.8 ± 23.5 | n.a | 0.272 |
| BAL cellular analysis | ||||
| - % Macrophage | 74.5 ± 21.1 | 65 ± 21.9 | 82 ± 15.3 | 0.0257 |
| - % Lymphocytes | 12.2 ± 9.5 | 12 ± 15.5 | 15.6 ± 12.1 | 0.2598 |
| - % Neutrophils | 11.2 ± 12.6 | 18 ± 17.1 | 5.4 ± 6.3 | 0.0140 |
| - % Eosinophils | 2.7 ± 4.1 | 5.6 ± 6.2 | 2.2 ± 1.6 | 0.1568 |