Table 3.
Effect of the exposure of alveolar epithelial lung A549 cells to Cop and CopNc (200 μg·mL−1 based on the theoretical amount of Cop) on the frequencies of DNA alterations per 1000 binucleated cells.
| Treatment | MN | NPB | NBUD | NDI |
|---|---|---|---|---|
| NC | 8 ± 2.0 | 6 ± 2 | 13 ± 2 | 1.9 ± 0.01 |
| PC | 41 ± 3 * | 18 ± 4 * | 54 ± 6 * | 1.8 ± 0.10 |
| Cop | 9 ± 2 | 7 ± 2 | 17 ± 5 | 1.9 ± 0.02 |
| CopNc | 7 ± 2 | 4 ± 1 | 14 ± 4 | 1.9 ± 0.02 |
NC: negative control; PC: positive control; MN: micronucleus; NPB: nucleoplasmatic bridges; NBUD: nuclear buds; NDI: nuclear division index; Cop: free copaiba oil; CopNc: copaiba oil-loaded nanocapsules; *: p < 0.05.